Plasma cell survival in the absence of B cell memory.
Nat Commun
; 8(1): 1781, 2017 11 24.
Article
en En
| MEDLINE
| ID: mdl-29176567
ABSTRACT
Pre-existing serum antibodies play an important role in vaccine-mediated protection against infection but the underlying mechanisms of immune memory are unclear. Clinical studies indicate that antigen-specific antibody responses can be maintained for many years, leading to theories that reactivation/differentiation of memory B cells into plasma cells is required to sustain long-term antibody production. Here, we present a decade-long study in which we demonstrate site-specific survival of bone marrow-derived plasma cells and durable antibody responses to multiple virus and vaccine antigens in rhesus macaques for years after sustained memory B cell depletion. Moreover, BrdU+ cells with plasma cell morphology can be detected for 10 years after vaccination/BrdU administration, indicating that plasma cells may persist for a prolonged period of time in the absence of cell division. On the basis of these results, long-lived plasma cells represent a key cell population responsible for long-term antibody production and serological memory.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células Plasmáticas
/
Linfocitos B
/
Memoria Inmunológica
Límite:
Animals
Idioma:
En
Año:
2017
Tipo del documento:
Article