Increased herpes zoster risk associated with poor HLA-A immediate early 62 protein (IE62) affinity.
Immunogenetics
; 70(6): 363-372, 2018 06.
Article
en En
| MEDLINE
| ID: mdl-29196796
ABSTRACT
Around 30% of individuals will develop herpes zoster (HZ), caused by the varicella zoster virus (VZV), during their life. While several risk factors for HZ, such as immunosuppressive therapy, are well known, the genetic and molecular components that determine the risk of otherwise healthy individuals to develop HZ are still poorly understood. We created a computational model for the Human Leukocyte Antigen (HLA-A, -B, and -C) presentation capacity of peptides derived from the VZV Immediate Early 62 (IE62) protein. This model could then be applied to a HZ cohort with known HLA molecules. We found that HLA-A molecules with poor VZV IE62 presentation capabilities were more common in a cohort of 50 individuals with a history of HZ compared to a nationwide control group, which equated to a HZ risk increase of 60%. This tendency was most pronounced for cases of HZ at a young age, where other risk factors are less prevalent. These findings provide new molecular insights into the development of HZ and reveal a genetic predisposition in those individuals most at risk to develop HZ.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antígenos HLA-A
/
Transactivadores
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Proteínas del Envoltorio Viral
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Proteínas Inmediatas-Precoces
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Herpesvirus Humano 3
/
Herpes Zóster
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
País como asunto:
Europa
Idioma:
En
Año:
2018
Tipo del documento:
Article