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Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis.
Wang, Xueqing; Liu, Bo; Searle, Xenia; Yeung, Clinton; Bogdan, Andrew; Greszler, Stephen; Singh, Ashvani; Fan, Yihong; Swensen, Andrew M; Vortherms, Timothy; Balut, Corina; Jia, Ying; Desino, Kelly; Gao, Wenqing; Yong, Hong; Tse, Chris; Kym, Philip.
  • Wang X; Research and Development, AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Liu B; Research and Development, AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Searle X; Research and Development, AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Yeung C; Research and Development, AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Bogdan A; Research and Development, AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Greszler S; Research and Development, AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Singh A; Research and Development, AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Fan Y; Research and Development, AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Swensen AM; Research and Development, AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Vortherms T; Research and Development, AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Balut C; Research and Development, AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Jia Y; Research and Development, AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Desino K; Research and Development, AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Gao W; Research and Development, AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Yong H; Research and Development, AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Tse C; Research and Development, AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Kym P; Research and Development, AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
J Med Chem ; 61(4): 1436-1449, 2018 02 22.
Article en En | MEDLINE | ID: mdl-29251932
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Benzoatos / Regulador de Conductancia de Transmembrana de Fibrosis Quística / Fibrosis Quística / Descubrimiento de Drogas Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Benzoatos / Regulador de Conductancia de Transmembrana de Fibrosis Quística / Fibrosis Quística / Descubrimiento de Drogas Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article