Quinoline-Based Hybrid Compounds with Antimalarial Activity.
Molecules
; 22(12)2017 Dec 19.
Article
en En
| MEDLINE
| ID: mdl-29257067
ABSTRACT
The application of quinoline-based compounds for the treatment of malaria infections is hampered by drug resistance. Drug resistance has led to the combination of quinolines with other classes of antimalarials resulting in enhanced therapeutic outcomes. However, the combination of antimalarials is limited by drug-drug interactions. In order to overcome the aforementioned factors, several researchers have reported hybrid compounds prepared by reacting quinoline-based compounds with other compounds via selected functionalities. This review will focus on the currently reported quinoline-based hybrid compounds and their preclinical studies.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Quinolinas
/
Malaria
/
Antimaláricos
Límite:
Animals
/
Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article