Microwave-assisted synthesis of novel 5-substituted benzylidene amino-2-butyl benzofuran-3-yl-4-methoxyphenyl methanones as antileishmanial and antioxidant agents.
Bioorg Med Chem Lett
; 28(3): 482-487, 2018 02 01.
Article
en En
| MEDLINE
| ID: mdl-29258770
ABSTRACT
A series of 5-substitutedbenzylideneamino-2-butylbenzofuran-3-yl-4-methoxyphenyl methanones is synthesized and evaluated for antileishmanial and antioxidant activities. Compounds 4f (IC50â¯=â¯52.0⯱â¯0.09⯵g/ml), 4h (IC50â¯=â¯56.0⯱â¯0.71⯵g/ml) and 4l (IC50â¯=â¯59.3⯱â¯0.55⯵g/ml) were shown significant antileishmanial when compared with standard sodium stibogluconate (IC50â¯=â¯490.0⯱â¯1.5⯵g/ml). Antioxidant study revealed that compounds 4i (IC50â¯=â¯2.44⯱â¯0.47⯵g/ml) and 4l (IC50â¯=â¯3.69⯱â¯0.44⯵g/ml) have shown potent comparable activity when compared with standard ascorbic acid (IC50â¯=â¯3.31⯱â¯0.34⯵g/ml). Molecular docking study was carried out which replicating results of biological activity in case of initial hits 4f and 4h suggesting that these compounds have a potential to become lead molecules in drug discovery process. In silico ADME study was performed for predicting pharmacokinetic profile of the synthesised antileishmanial agents and expressed good oral drug like behaviour.
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Banco de datos:
MEDLINE
Asunto principal:
Benzofuranos
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Compuestos de Bencilideno
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Leishmania donovani
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Microondas
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Antioxidantes
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Antiprotozoarios
Idioma:
En
Año:
2018
Tipo del documento:
Article