Med1 deficiency alters the somatic hypermutation spectrum in murine B cells.
Eur J Immunol
; 48(4): 720-723, 2018 04.
Article
en En
| MEDLINE
| ID: mdl-29293266
ABSTRACT
The Mediator complex is known to orchestrate transcription. Here we show that B cell conditional deficient mice for the Med1 subunit display robust somatic hypermutation. Nevertheless, the mutation frequency at A residues is decreased and the expected A/T ratio is abolished, implicating Mediator in the second phase of somatic hypermutation.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos B
/
Hipermutación Somática de Inmunoglobulina
/
Subunidad 1 del Complejo Mediador
Límite:
Animals
Idioma:
En
Año:
2018
Tipo del documento:
Article