Methyl chanofruticosinate type alkaloids from the aerial parts of Kopsia lancibracteolata Merr.
J Asian Nat Prod Res
; 21(3): 227-233, 2019 Mar.
Article
en En
| MEDLINE
| ID: mdl-29295627
ABSTRACT
A chemical investigation on the 70% ethanol extract from the leaves and stems of Kopsia lancibracteolata Merr. resulted in the isolation of three new methyl chanofruticosinate type alkaloids, 12-hydroxyl prunifoline A (1), 12-hydroxyl prunifoline C (2), and N(4)-oxide prunifoline D (3). Structural elucidation of all the compounds was performed by spectral methods such as 1D- and 2D-NMR, IR, UV, and HR-ESI-MS. The isolated alkaloids were tested in vitro for cytotoxic potential against five tumor cell lines (BGC-823, HepG2, MCF-7, SGC-7901, and SK-MEL-2). As a result, alkaloid 3 exhibited significant cytotoxic activity against all tested tumor cell lines with IC50 values from 7.2 to 8.9 µM.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Apocynaceae
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Alcaloides Indólicos
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Componentes Aéreos de las Plantas
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Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Año:
2019
Tipo del documento:
Article