Medication adherence and adverse effect profile of antiepileptic drugs in Nigerian patients with epilepsy.
Neurodegener Dis Manag
; 8(1): 25-36, 2018 02.
Article
en En
| MEDLINE
| ID: mdl-29308710
ABSTRACT
AIM:
Medication adherence remains a major challenge among patients with epilepsy (PWE) with the adverse effect profile of antiepileptic drugs (AEDs) as one of its main drivers.METHODS:
This was a cross-sectional questionnaire-based study among PWE in selected Nigerian tertiary healthcare facilities using the Morisky Medication Adherence Scale and the Liverpool Adverse Effect Profile (LAEP).RESULTS:
126 PWE from four tertiary healthcare facilities were included in this study comprising of 59 (46.8%) males and 67 (53.2%) females. Carbamazepine (104/70.7%), sodium valproate (23/15.6%) and phenytoin (11/7.5%) were the most commonly prescribed AEDs. Using the Morisky Medication Adherence Scale, 17.2, 38.3 and 44.5% of patients were classified as having high, medium and low adherence, respectively. The mean LAEP score was 23.69 ± 6.07. The most common reported adverse effects among respondents were tiredness (30.4%) and headache (22.5%).CONCLUSION:
Medication adherence to AED was poor among patients in this study.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Epilepsia
/
Cumplimiento de la Medicación
/
Anticonvulsivantes
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Adult
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Female
/
Humans
/
Male
País como asunto:
Africa
Idioma:
En
Año:
2018
Tipo del documento:
Article