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Altered hemoglobin co-factor sensitivity does not underlie the evolution of derived fossorial specializations in the family Talpidae.
Campbell, Kevin L; Gaudry, Michael J; He, Kai; Suzuki, Hitoshi; Zhang, Ya-Ping; Jiang, Xue-Long; Weber, Roy E.
  • Campbell KL; Department of Biological Sciences, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada. Electronic address: Kevin.Campbell@umanitoba.ca.
  • Gaudry MJ; Department of Biological Sciences, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.
  • He K; Department of Biological Sciences, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.
  • Suzuki H; Laboratory of Ecology and Genetics, Graduate School of Environmental Science, Hokkaido University, Kita-ku, Sapporo 060-0810, Japan.
  • Zhang YP; Laboratory of Molecular Biology of Domestic Animals, and Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
  • Jiang XL; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
  • Weber RE; Aarhus University, Department of Bioscience, Faculty of Science and Technology, 8000 Aarhus C, Denmark.
Article en En | MEDLINE | ID: mdl-29309911
The high O2 affinity of European mole (Talpa europaea) blood is postulated to largely arise from the presence of two ß-globin chain residues (ß4 Ser and ß5 Gly) that weaken the interaction of its hemoglobin (Hb) with the red cell organophosphate 2,3-diphosphoglycerate (DPG). This latter trait is generally accepted to be an 'adaptation to subterranean life', despite the fact that no data are available for more basal mole lineages that have no evolutionary history of fossoriality (i.e. the ambulatory, high-elevation shrew-like moles and the semi-aquatic desmans), and which may similarly benefit from an elevated blood O2 affinity. To test whether evolution of a low DPG sensitivity phenotype is linked to derived fossorial lifestyles or represents an ancestral trait for the family, we determined the globin gene sequences and measured the intrinsic O2 affinity and co-factor sensitivity of the major Hb component of the gracile shrew-like mole (Uropsilus gracilis) and the Pyrenean desman (Galemys pyrenaicus). Our results unequivocally demonstrate that the presence of ß4 Ser and ß5 Gly, together with a low DPG sensitivity Hb phenotype, predates the radiation of the family Talpidae, and hence did not evolve as a specific adaptation to fossorial life. By contrast, our comparative analyses suggest that variations in whole blood O2 affinity among members of this family predominantly arose from amino acid substitutions that increase or decrease the intrinsic O2 affinity of the protein.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxígeno / Hemoglobinas / Evolución Biológica / Topos Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Año: 2018 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxígeno / Hemoglobinas / Evolución Biológica / Topos Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Año: 2018 Tipo del documento: Article