Antibiotic Resistance Plasmids Cointegrated into a Megaplasmid Harboring the blaOXA-427 Carbapenemase Gene.
Antimicrob Agents Chemother
; 62(3)2018 03.
Article
en En
| MEDLINE
| ID: mdl-29311088
ABSTRACT
OXA-427 is a new class D carbapenemase encountered in different species of Enterobacteriaceae in a Belgian hospital. To study the dispersal of this gene, we performed a comparative analysis of two plasmids containing the blaOXA-427 gene, isolated from a Klebsiella pneumoniae strain and an Enterobacter cloacae complex strain. The two IncA/C2 plasmids containing blaOXA-427 share the same backbone; in the K. pneumoniae strain, however, this plasmid is cointegrated into an IncFIb plasmid, forming a 321-kb megaplasmid with multiple multiresistance regions.
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Banco de datos:
MEDLINE
Asunto principal:
Plásmidos
/
Proteínas Bacterianas
/
Beta-Lactamasas
Idioma:
En
Año:
2018
Tipo del documento:
Article