Quality of life with ablation or medical therapy for ventricular arrhythmias: A substudy of VANISH.
J Cardiovasc Electrophysiol
; 29(3): 421-434, 2018 03.
Article
en En
| MEDLINE
| ID: mdl-29316012
ABSTRACT
BACKGROUND/OBJECTIVE:
We compared health-related quality of life (HRQoL) in patients randomized to escalated therapy and those randomized to ablation for ventricular tachycardia in the VANISH trial.METHODS:
HRQoL was assessed among VANISH patients at baseline and 3-, 6-, and 12-month follow-up visits. Four validated instruments were used the SF-36, the implanted cardioverter defibrillator (ICD) Concerns questionnaire (ICDC), the Hospital Anxiety and Depression Scale (HADS), and the EuroQol five dimensions questionnaire (EQ-5D). Linear mixed-effects modeling was used for repeated measures with SF-36, HADS, ICDC, and EQ-5D as dependent variables. In a second model, treatment was subdivided by amiodarone use prior to enrollment.RESULTS:
HRQoL did not differ significantly between those randomized to ablation or escalated therapy. On subgroup analysis, improvement in SF-36 measures was seen at 6 months in the ablation group for social functioning (63.5-69.3, P = 0.03) and energy/fatigue (43.0-47.9, P = 0.01). ICDC measures showed a reduction in ICD concern in the ablation group at 6 months (10.4-8.7, P = 0.01) and a reduction in ICD concern in the escalated therapy group at 6 months (10.9-9.4, P = 0.04). EQ-5D measures showed a significant improvement in overall health in ablation patients at 6 months (63.4-67.3, P = 0.04).CONCLUSION:
Patients in the VANISH study randomized to ablation did not have a significant change in quality of life outcomes compared to those randomized to escalated therapy. Some subgroup findings were significant, as those randomized to ablation showed persistent improvement in SF-36 energy/fatigue and ICD concern, and transient improvement in SF-36 social functioning and EQ-5D overall health.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Calidad de Vida
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Taquicardia Ventricular
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Ablación por Catéter
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Amiodarona
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Antiarrítmicos
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
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Prognostic_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
País como asunto:
America do norte
/
Europa
/
Oceania
Idioma:
En
Año:
2018
Tipo del documento:
Article