B1a B cells require autophagy for metabolic homeostasis and self-renewal.
J Exp Med
; 215(2): 399-413, 2018 02 05.
Article
en En
| MEDLINE
| ID: mdl-29326381
ABSTRACT
Specific metabolic programs are activated by immune cells to fulfill their functional roles, which include adaptations to their microenvironment. B1 B cells are tissue-resident, innate-like B cells. They have many distinct properties, such as the capacity to self-renew and the ability to rapidly respond to a limited repertoire of epitopes. The metabolic pathways that support these functions are unknown. We show that B1 B cells are bioenergetically more active than B2 B cells, with higher rates of glycolysis and oxidative phosphorylation, and depend on glycolysis. They acquire exogenous fatty acids and store lipids in droplet form. Autophagy is differentially activated in B1a B cells, and deletion of the autophagy gene Atg7 leads to a selective loss of B1a B cells caused by a failure of self-renewal. Autophagy-deficient B1a B cells down-regulate critical metabolic genes and accumulate dysfunctional mitochondria. B1 B cells, therefore, have evolved a distinct metabolism adapted to their residence and specific functional properties.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Subgrupos de Linfocitos B
Límite:
Animals
Idioma:
En
Año:
2018
Tipo del documento:
Article