Single-Cell Genomics: A Stepping Stone for Future Immunology Discoveries.
Cell
; 172(1-2): 14-21, 2018 01 11.
Article
en En
| MEDLINE
| ID: mdl-29328909
ABSTRACT
The immunology field has invested great efforts and ingenuity to characterize the various immune cell types and elucidate their functions. However, accumulating evidence indicates that current technologies and classification schemes are limited in their ability to account for the functional heterogeneity of immune processes. Single-cell genomics hold the potential to revolutionize the way we characterize complex immune cell assemblies and study their spatial organization, dynamics, clonal distribution, pathways, function, and crosstalks. In this Perspective, we consider recent and forthcoming technological and analytical advances in single-cell genomics and the potential impact of those advances on the future of immunology research and immunotherapy.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Técnicas Inmunológicas
/
Genómica
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Análisis de la Célula Individual
Límite:
Animals
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Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article