Polymeric microspheres of okra mucilage and alginate for the controlled release of oxcarbazepine: In vitro &in vivo evaluation.
Int J Biol Macromol
; 111: 1156-1165, 2018 May.
Article
en En
| MEDLINE
| ID: mdl-29337102
ABSTRACT
Oxcarbazepine-loaded alginate/okra pods mucilage microspheres were prepared through inotropic gelation technique for the sustained release of oxcarbazepine. The drug encapsulating efficiency of these microspheres was found 76.22⯱â¯0.01% to 90.57⯱â¯0.02% and their average particle sizes were 496⯵m⯱â¯0.41 to 692⯵m⯱â¯0.22. These microspheres were characterized in terms of swelling capacity, FTIR, DSC and SEM analysis. The in vitro drug release from these microspheres was followed sustained release (Korsemeyer - Peppas model) pattern (R2â¯=â¯0.9552-0.9906) and value of nâ¯>â¯1 showed that drug released by anomalous (non-Fickian) diffusion. The in vivo studies showed that there were highly significant difference with pâ¯<â¯0.001 in the pharmacokinetic parameters (Cmax, t½, AUC0-∞, Ke), when oxcarbazepine was formulated in form of polymeric microspheres as compared to pure drug.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Polímeros
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Carbamazepina
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Sistemas de Liberación de Medicamentos
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Abelmoschus
Límite:
Animals
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Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article