Efficacy of minimal doses of an American hepatitis B vaccine in neonates.
Clin Ther
; 7(6): 680-3, 1985.
Article
en En
| MEDLINE
| ID: mdl-2934134
ABSTRACT
Eight neonates and three young children at risk for hepatitis B infection were vaccinated with minimal doses of inactivated hepatitis B vaccine. The purpose of the study was to evaluate the efficacy of low doses with a view toward reducing the cost of immunization and therefore extending the practice to a larger number of subjects and minimizing the incidence of adverse reactions to the vaccine. The patients received two intramuscular injections (0.1 ml) of vaccine at a two-month interval and a booster six months after the first dose. Anti-HBs titers were determined simultaneously by radioimmunoassay on all serum samples collected. Five of the 11 patients achieved presumably protective (greater than 10 mU/ml) antibody levels within six months after the first dose (titers between 10 and 74 mU/ml), and all but one patient achieved titers between 27 and 2,500 mU/ml within two months after the booster. No adverse reaction was observed.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Recién Nacido
/
Vacunas contra Hepatitis Viral
/
Hepatitis B
/
Anticuerpos contra la Hepatitis B
Límite:
Child, preschool
/
Humans
/
Infant
Idioma:
En
Año:
1985
Tipo del documento:
Article