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Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes.
Mueller, Sebastian; Engleitner, Thomas; Maresch, Roman; Zukowska, Magdalena; Lange, Sebastian; Kaltenbacher, Thorsten; Konukiewitz, Björn; Öllinger, Rupert; Zwiebel, Maximilian; Strong, Alex; Yen, Hsi-Yu; Banerjee, Ruby; Louzada, Sandra; Fu, Beiyuan; Seidler, Barbara; Götzfried, Juliana; Schuck, Kathleen; Hassan, Zonera; Arbeiter, Andreas; Schönhuber, Nina; Klein, Sabine; Veltkamp, Christian; Friedrich, Mathias; Rad, Lena; Barenboim, Maxim; Ziegenhain, Christoph; Hess, Julia; Dovey, Oliver M; Eser, Stefan; Parekh, Swati; Constantino-Casas, Fernando; de la Rosa, Jorge; Sierra, Marta I; Fraga, Mario; Mayerle, Julia; Klöppel, Günter; Cadiñanos, Juan; Liu, Pentao; Vassiliou, George; Weichert, Wilko; Steiger, Katja; Enard, Wolfgang; Schmid, Roland M; Yang, Fengtang; Unger, Kristian; Schneider, Günter; Varela, Ignacio; Bradley, Allan; Saur, Dieter; Rad, Roland.
  • Mueller S; Center for Translational Cancer Research (TranslaTUM), Technische Universität München, 81675 Munich, Germany.
  • Engleitner T; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Maresch R; Center for Translational Cancer Research (TranslaTUM), Technische Universität München, 81675 Munich, Germany.
  • Zukowska M; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Lange S; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Kaltenbacher T; Center for Translational Cancer Research (TranslaTUM), Technische Universität München, 81675 Munich, Germany.
  • Konukiewitz B; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Öllinger R; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Zwiebel M; Center for Translational Cancer Research (TranslaTUM), Technische Universität München, 81675 Munich, Germany.
  • Strong A; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Yen HY; Center for Translational Cancer Research (TranslaTUM), Technische Universität München, 81675 Munich, Germany.
  • Banerjee R; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Louzada S; Center for Translational Cancer Research (TranslaTUM), Technische Universität München, 81675 Munich, Germany.
  • Fu B; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Seidler B; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Götzfried J; Institute of Pathology, Technische Universität München, 81675 Munich, Germany.
  • Schuck K; Center for Translational Cancer Research (TranslaTUM), Technische Universität München, 81675 Munich, Germany.
  • Hassan Z; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Arbeiter A; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Schönhuber N; The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Klein S; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Veltkamp C; Comparative Experimental Pathology, Technische Universität München, 81675 Munich, Germany.
  • Friedrich M; The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Rad L; The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Barenboim M; The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Ziegenhain C; Center for Translational Cancer Research (TranslaTUM), Technische Universität München, 81675 Munich, Germany.
  • Hess J; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Dovey OM; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Eser S; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Parekh S; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Constantino-Casas F; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • de la Rosa J; Center for Translational Cancer Research (TranslaTUM), Technische Universität München, 81675 Munich, Germany.
  • Sierra MI; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Fraga M; Center for Translational Cancer Research (TranslaTUM), Technische Universität München, 81675 Munich, Germany.
  • Mayerle J; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Klöppel G; Center for Translational Cancer Research (TranslaTUM), Technische Universität München, 81675 Munich, Germany.
  • Cadiñanos J; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Liu P; The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Vassiliou G; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Weichert W; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Steiger K; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Enard W; Anthropology & Human Genomics, Department of Biology II, Ludwig-Maximilians Universität, 82152 Martinsried, Germany.
  • Schmid RM; Helmholtz Zentrum München, Research Unit Radiation Cytogenetics, 85764 Neuherberg, Germany.
  • Yang F; The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Unger K; Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Schneider G; Anthropology & Human Genomics, Department of Biology II, Ludwig-Maximilians Universität, 82152 Martinsried, Germany.
  • Varela I; Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK.
  • Bradley A; The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Saur D; Instituto de Medicina Oncológica y Molecular de Asturias (IMOMA), 33193 Oviedo, Spain.
  • Rad R; Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain.
Nature ; 554(7690): 62-68, 2018 02 01.
Article en En | MEDLINE | ID: mdl-29364867
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Proteínas Proto-Oncogénicas p21(ras) / Dosificación de Gen / Evolución Molecular / Carcinoma Ductal Pancreático Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Proteínas Proto-Oncogénicas p21(ras) / Dosificación de Gen / Evolución Molecular / Carcinoma Ductal Pancreático Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Año: 2018 Tipo del documento: Article