IgE-expressing memory B cells and plasmablasts are increased in blood of children with asthma, food allergy, and atopic dermatitis.
Allergy
; 73(6): 1331-1336, 2018 06.
Article
en En
| MEDLINE
| ID: mdl-29380876
ABSTRACT
Despite the critical role of soluble IgE in the pathology of IgE-mediated allergic disease, little is known about abnormalities in the memory B cells and plasma cells that produce IgE in allergic patients. We here applied a flow cytometric approach to cross-sectionally study blood IgE+ memory B cells and plasmablasts in 149 children with atopic dermatitis, food allergy, and/or asthma and correlated these to helper T(h)2 cells and eosinophils. Children with allergic disease had increased numbers of IgE+CD27- and IgE+CD27+ memory B cells and IgE+ plasmablasts, as well as increased numbers of eosinophils and Th2 cells. IgE+ plasmablast numbers correlated positively with Th2 cell numbers. These findings open new possibilities for diagnosis and monitoring of treatment in patients with allergic diseases.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células Plasmáticas
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Asma
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Linfocitos B
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Dermatitis Atópica
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Hipersensibilidad a los Alimentos
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Memoria Inmunológica
Límite:
Adolescent
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Child
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Female
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Humans
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Male
Idioma:
En
Año:
2018
Tipo del documento:
Article