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Anti-PD-1/anti-CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8+ T cell trafficking.
Taggart, David; Andreou, Tereza; Scott, Karen J; Williams, Jennifer; Rippaus, Nora; Brownlie, Rebecca J; Ilett, Elizabeth J; Salmond, Robert J; Melcher, Alan; Lorger, Mihaela.
  • Taggart D; Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, United Kingdom.
  • Andreou T; MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9YL, United Kingdom.
  • Scott KJ; Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, United Kingdom.
  • Williams J; Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, United Kingdom.
  • Rippaus N; Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, United Kingdom.
  • Brownlie RJ; Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, United Kingdom.
  • Ilett EJ; Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, United Kingdom.
  • Salmond RJ; Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, United Kingdom.
  • Melcher A; Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, United Kingdom.
  • Lorger M; Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, United Kingdom.
Proc Natl Acad Sci U S A ; 115(7): E1540-E1549, 2018 02 13.
Article en En | MEDLINE | ID: mdl-29386395
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Melanoma Experimental / Neoplasias Encefálicas / Linfocitos T Citotóxicos / Linfocitos Infiltrantes de Tumor / Linfocitos T Reguladores / Linfocitos T CD8-positivos / Anticuerpos Monoclonales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Melanoma Experimental / Neoplasias Encefálicas / Linfocitos T Citotóxicos / Linfocitos Infiltrantes de Tumor / Linfocitos T Reguladores / Linfocitos T CD8-positivos / Anticuerpos Monoclonales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2018 Tipo del documento: Article