Contribution to Malaria Transmission of Symptomatic and Asymptomatic Parasite Carriers in Cambodia.
J Infect Dis
; 217(10): 1561-1568, 2018 04 23.
Article
en En
| MEDLINE
| ID: mdl-29394367
ABSTRACT
Background:
Eliminating falciparum malaria in Cambodia is a top priority, requiring the implementation of novel tools and strategies to interrupt its transmission. To date, few data are available regarding the contributions to malaria transmission of symptomatic and asymptomatic carriers.Methods:
Direct-membrane and skin feeding assays (DMFAs, SFAs) were performed, using Anopheles minimus and Anopheles dirus, to determine infectivity of symptomatic falciparum-infected patients and malaria asymptomatic carriers; a subset of the latter were followed up for 2 months to assess their transmission potential.Results:
By microscopy and real-time polymerase chain reaction, Plasmodium falciparum gametocyte prevalence rates were, respectively, 19.3% (n = 21/109) and 44% (n = 47/109) on day (D) 0 and 17.9% (n = 5/28) and 89.3% (n = 25/28) in recrudescent patients (Drec) (RT-PCR Drec vs D0 P = .002). Falciparum malaria patient infectivity was low on D0 (6.2%; n = 3/48) and in Drec (8.3%; n = 1/12). Direct-membrane feeding assays and SFAs gave similar results. None of the falciparum (n = 0/19) and 3 of 28 Plasmodium vivax asymptomatic carriers were infectious to mosquitoes, including those that were followed up for 2 months. Overall, P. falciparum gametocytemias were low except in a few symptomatic carriers.Conclusions:
Only symptomatic falciparum malaria patients were infectious to mosquito vectors at baseline and recrudescence, highlighting the need to detect promptly and treat effectively P. falciparum patients.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Parásitos
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Plasmodium falciparum
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Malaria Falciparum
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Mosquitos Vectores
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Anopheles
Tipo de estudio:
Clinical_trials
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Diagnostic_studies
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Prevalence_studies
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Risk_factors_studies
Límite:
Adult
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Animals
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Child
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Female
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Humans
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Male
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Middle aged
País como asunto:
Asia
Idioma:
En
Año:
2018
Tipo del documento:
Article