A hybrid of coumarin and phenylsulfonylfuroxan induces caspase-dependent apoptosis and cytoprotective autophagy in lung adenocarcinoma cells.

Wang, Qian; Guo, Yalan; Jiang, Shanshan; Dong, Mengxue; Kuerban, Kudelaidi; Li, Jiyang; Feng, Meiqing; Chen, Ying; Ye, Li

Wang, Qian; Guo, Yalan; Jiang, Shanshan; Dong, Mengxue; Kuerban, Kudelaidi; Li, Jiyang; Feng, Meiqing; Chen, Ying; Ye, Li.

Wang Q; Department of Microbiological & Biochemical Pharmacy, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Guo Y; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, China.
Jiang S; Department of Microbiological & Biochemical Pharmacy, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Dong M; Department of Microbiological & Biochemical Pharmacy, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Kuerban K; Department of Microbiological & Biochemical Pharmacy, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Li J; Department of Microbiological & Biochemical Pharmacy, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Feng M; Department of Microbiological & Biochemical Pharmacy, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Chen Y; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, China.
Ye L; Department of Microbiological & Biochemical Pharmacy, School of Pharmacy, Fudan University, Shanghai, 201203, China. Electronic address: yelil@fudan.edu.cn.

Phytomedicine ; 39: 160-167, 2018 Jan 15.

Article en En | MEDLINE | ID: mdl-29433677

Asunto(s)

Adenocarcinoma/tratamiento farmacológico; Antineoplásicos/química; Antineoplásicos/farmacología; Autofagia/efectos de los fármacos; Neoplasias Pulmonares/tratamiento farmacológico; Oxadiazoles/química; Células A549; Adenocarcinoma/patología; Adenocarcinoma del Pulmón; Apoptosis/efectos de los fármacos; Apoptosis/fisiología; Proteína 5 Relacionada con la Autofagia/genética; Proteína 5 Relacionada con la Autofagia/metabolismo; Caspasas/metabolismo; Línea Celular Tumoral; Cumarinas/química; Humanos; Neoplasias Pulmonares/patología; Óxido Nítrico/metabolismo; Transducción de Señal/efectos de los fármacos; Serina-Treonina Quinasas TOR/metabolismo

Palabras clave

Apoptosis; Autophagy; Coumarin; Lung adenocarcinoma; Phenylsulfonylfuroxan

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxadiazoles / Autofagia / Adenocarcinoma / Neoplasias Pulmonares / Antineoplásicos Límite: Humans Idioma: En Año: 2018 Tipo del documento: Article

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