Independent validation of a new reirradiation risk score (RRRS) for glioma patients predicting post-recurrence survival: A multicenter DKTK/ROG analysis.
Radiother Oncol
; 127(1): 121-127, 2018 04.
Article
en En
| MEDLINE
| ID: mdl-29433917
ABSTRACT
BACKGROUND AND PURPOSE:
Reirradiation (reRT) is a valid option with considerable efficacy in patients with recurrent high-grade glioma, but it is still not known which patients might be optimal candidates for a second course of irradiation. This study validated a newly developed prognostic score independently in an external patient cohort. MATERIAL ANDMETHODS:
The reRT risk score (RRRS) is based on a linear combination of initial histology, clinical performance status, and age derived from a multivariable model of 353 patients. This score can predict post-recurrence survival (PRS) after reRT. The validation dataset consisted of 212 patients.RESULTS:
The RRRS differentiates three prognostic groups. Discrimination and calibration were maintained in the validation group. Median PRS times in the development cohort for the good/intermediate/poor risk categories were 14.2, 9.1, and 5.3â¯months, respectively. The respective groups within the validation cohort displayed median PRS times of 13.8, 8.8, and 3.8â¯months, respectively. Uno's C for development data was 0.64 (CI 0.60-0.69) and for validation data 0.63 (CI 0.58-0.68).CONCLUSIONS:
The RRRS has been successfully validated in an independent patient cohort. This linear combination of three easily determined clinicopathological factors allows for a reliable classification of patients and may be used as stratification factor for future trials.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Reirradiación
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Glioma
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Recurrencia Local de Neoplasia
Tipo de estudio:
Etiology_studies
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Incidence_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País como asunto:
Europa
Idioma:
En
Año:
2018
Tipo del documento:
Article