Could Low-Protein Diet Modulate Nrf2 Pathway in Chronic Kidney Disease?
J Ren Nutr
; 28(4): 229-234, 2018 07.
Article
en En
| MEDLINE
| ID: mdl-29452888
ABSTRACT
Oxidative stress and inflammation are common findings in chronic kidney disease (CKD) patients, and they are directly linked to clinical outcomes such as protein energy wasting and cardiovascular disease. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is the master regulator of antioxidant genes, regulating the expression of detoxifying enzymes of phase II and antioxidant responses. Furthermore, Nrf2 can also regulate anti-inflammatory cellular responses, by inhibiting nuclear factor kappa B activity (transcription factor that promotes inflammation). Therefore, modulating Nrf2 can be a new therapeutic approach to reduce inflammation and oxidative stress in CKD. Low-protein diet (LPD) prescribed for nondialysis CKD patients presents numerous benefits already well established, including reduction of inflammation and oxidative stress. However, there is no available data regarding the relationship between LPD and Nrf2 modulation in these patients. This review aims to discuss the impact, if any, of LPD on Nrf2 expression, in nondialysis CKD patients.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Dieta con Restricción de Proteínas
/
Insuficiencia Renal Crónica
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Factor 2 Relacionado con NF-E2
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Inflamación
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article