Super-Enhancer-Driven Long Non-Coding RNA LINC01503, Regulated by TP63, Is Over-Expressed and Oncogenic in Squamous Cell Carcinoma.

Xie, Jian-Jun; Jiang, Yan-Yi; Jiang, Yuan; Li, Chun-Quan; Lim, Mei-Chee; An, Omer; Mayakonda, Anand; Ding, Ling-Wen; Long, Lin; Sun, Chun; Lin, Le-Hang; Chen, Li; Wu, Jian-Yi; Wu, Zhi-Yong; Cao, Qi; Fang, Wang-Kai; Yang, Wei; Soukiasian, Harmik; Meltzer, Stephen J; Yang, Henry; Fullwood, Melissa; Xu, Li-Yan; Li, En-Min; Lin, De-Chen; Koeffler, H Phillip

Xie, Jian-Jun; Jiang, Yan-Yi; Jiang, Yuan; Li, Chun-Quan; Lim, Mei-Chee; An, Omer; Mayakonda, Anand; Ding, Ling-Wen; Long, Lin; Sun, Chun; Lin, Le-Hang; Chen, Li; Wu, Jian-Yi; Wu, Zhi-Yong; Cao, Qi; Fang, Wang-Kai; Yang, Wei; Soukiasian, Harmik; Meltzer, Stephen J; Yang, Henry; Fullwood, Melissa; Xu, Li-Yan; Li, En-Min; Lin, De-Chen; Koeffler, H Phillip.

Xie JJ; Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou, China; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: g_jjxie@stu.edu.cn.
Jiang YY; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Jiang Y; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Li CQ; School of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing, China.
Lim MC; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
An O; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Mayakonda A; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Ding LW; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Long L; Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou, China.
Sun C; Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou, China.
Lin LH; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Chen L; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Wu JY; Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou, China.
Wu ZY; Department of Oncologic Surgery, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-Sen University, Shantou, China.
Cao Q; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Fang WK; Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou, China.
Yang W; Departments of Surgery and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
Soukiasian H; Division of Thoracic Surgery, Cedars-Sinai Medical Center, Los Angeles, California.
Meltzer SJ; Departments of Medicine and Oncology, the Johns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland.
Yang H; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Fullwood M; Cancer Science Institute of Singapore, National University of Singapore, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore.
Xu LY; Institute of Oncologic Pathology, Medical College of Shantou University, Shantou, China. Electronic address: lyxu@stu.edu.cn.
Li EM; Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou, China. Electronic address: nmli@stu.edu.cn.
Lin DC; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: De-Chen.Lin@cshs.org.
Koeffler HP; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California; Cancer Science Institute of Singapore, National University of Singapore, Singapore; National University Cancer Institute, National University Hospital Singapore, Singapore.

Gastroenterology ; 154(8): 2137-2151.e1, 2018 06.

Article en En | MEDLINE | ID: mdl-29454790

Asunto(s)

Carcinogénesis/genética; Carcinoma de Células Escamosas/genética; Neoplasias Esofágicas/genética; Regulación Neoplásica de la Expresión Génica; ARN Largo no Codificante/genética; Factores de Transcripción/genética; Proteínas Supresoras de Tumor/genética; Animales; Biomarcadores de Tumor/genética; Biomarcadores de Tumor/metabolismo; Carcinoma de Células Escamosas/mortalidad; Carcinoma de Células Escamosas/patología; Línea Celular Tumoral; China; Elementos de Facilitación Genéticos/genética; Neoplasias Esofágicas/mortalidad; Neoplasias Esofágicas/patología; Carcinoma de Células Escamosas de Esófago; Femenino; Perfilación de la Expresión Génica; Técnicas de Silenciamiento del Gen; Humanos; Masculino; Ratones; Ratones Desnudos; Persona de Mediana Edad; Interferencia de ARN; ARN Largo no Codificante/metabolismo; ARN Interferente Pequeño/metabolismo; Reacción en Cadena de la Polimerasa de Transcriptasa Inversa; Transducción de Señal/genética; Factores de Transcripción/metabolismo; Proteínas Supresoras de Tumor/metabolismo; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

Epigenetic Regulation; Gene Regulation; Oncongenesis; Signal Transduction

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Factores de Transcripción / Neoplasias Esofágicas / Carcinoma de Células Escamosas / Regulación Neoplásica de la Expresión Génica / Proteínas Supresoras de Tumor / ARN Largo no Codificante / Carcinogénesis Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male / Middle aged País como asunto: Asia Idioma: En Año: 2018 Tipo del documento: Article

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