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Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors.
Goel, Parul; Jumpertz, Thorsten; Tichá, Anezka; Ogorek, Isabella; Mikles, David C; Hubalek, Martin; Pietrzik, Claus U; Strisovsky, Kvido; Schmidt, Boris; Weggen, Sascha.
  • Goel P; Department of Neuropathology, Heinrich-Heine University Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany; Clemens Schoepf Institute for Organic Chemistry and Biochemistry, Technische Universitaet Darmstadt, Alarich-Weiss-Strasse 4-8, 64287 Darmstadt, Germany.
  • Jumpertz T; Department of Neuropathology, Heinrich-Heine University Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany.
  • Tichá A; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo n. 2, 166 10, Praha 6, Czech Republic.
  • Ogorek I; Department of Neuropathology, Heinrich-Heine University Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany.
  • Mikles DC; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo n. 2, 166 10, Praha 6, Czech Republic.
  • Hubalek M; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo n. 2, 166 10, Praha 6, Czech Republic.
  • Pietrzik CU; Institute for Pathobiochemistry, University Medical Center of the Johannes Gutenberg University Mainz, Duesbergweg 6, 55128 Mainz, Germany.
  • Strisovsky K; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo n. 2, 166 10, Praha 6, Czech Republic.
  • Schmidt B; Clemens Schoepf Institute for Organic Chemistry and Biochemistry, Technische Universitaet Darmstadt, Alarich-Weiss-Strasse 4-8, 64287 Darmstadt, Germany. Electronic address: schmidt_boris@t-online.de.
  • Weggen S; Department of Neuropathology, Heinrich-Heine University Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany. Electronic address: sweggen@hhu.de.
Bioorg Med Chem Lett ; 28(8): 1417-1422, 2018 05 01.
Article en En | MEDLINE | ID: mdl-29463448
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Estirenos / Inhibidores de Serina Proteinasa / Benzoxazinas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Estirenos / Inhibidores de Serina Proteinasa / Benzoxazinas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article