Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1&#945;.

Basu, Subhasree; Gnanapradeepan, Keerthana; Barnoud, Thibaut; Kung, Che-Pei; Tavecchio, Michele; Scott, Jeremy; Watters, Andrea; Chen, Qing; Kossenkov, Andrew V; Murphy, Maureen E

Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α.

Basu, Subhasree; Gnanapradeepan, Keerthana; Barnoud, Thibaut; Kung, Che-Pei; Tavecchio, Michele; Scott, Jeremy; Watters, Andrea; Chen, Qing; Kossenkov, Andrew V; Murphy, Maureen E.

Basu S; Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Gnanapradeepan K; Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Barnoud T; Graduate Group in Biochemistry and Biophysics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104.
Kung CP; Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Tavecchio M; Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Scott J; Program in Tumor Microenvironment and Metastasis, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Watters A; Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Chen Q; Program in Tumor Microenvironment and Metastasis, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Kossenkov AV; Program in Tumor Microenvironment and Metastasis, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Murphy ME; Program in Center for Systems and Computational Biology, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.

Genes Dev ; 32(3-4): 230-243, 2018 02 01.

Article en En | MEDLINE | ID: mdl-29463573

Asunto(s)

Genes p53; Mutación; Neoplasias/metabolismo; Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma/metabolismo; Animales; Neoplasias de la Mama/genética; Neoplasias de la Mama/metabolismo; Neoplasias de la Mama/mortalidad; Línea Celular Tumoral; Movimiento Celular; Femenino; Factor Nuclear 4 del Hepatocito/metabolismo; Humanos; Masculino; Ratones; Invasividad Neoplásica; Metástasis de la Neoplasia; Neoplasias/genética; Neoplasias/patología; Fosforilación Oxidativa; Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma/antagonistas & inhibidores

Palabras clave

PGC-1α; codon 72; metastasis; mutant p53; oxidative phosphorylation

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Genes p53 / Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma / Mutación / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Año: 2018 Tipo del documento: Article

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