Intraocular pressure elevation after cataract surgery and its prevention by oral acetazolamide in eyes with pseudoexfoliation syndrome.
J Cataract Refract Surg
; 44(2): 175-181, 2018 Feb.
Article
en En
| MEDLINE
| ID: mdl-29525617
ABSTRACT
PURPOSE:
To examine whether intraocular pressure (IOP) increases immediately after cataract surgery in eyes with pseudoexfoliation (PXF) syndrome and to assess whether orally administered acetazolamide can prevent the IOP elevation.SETTING:
Hayashi Eye Hospital, Fukuoka, Japan.DESIGN:
Prospective case series.METHODS:
Patients with PXF syndrome scheduled for phacoemulsification were randomly assigned to 1 of 3 groups (1) oral acetazolamide administered 1 hour preoperatively (preoperative administration group), (2) administered 3 hours postoperatively (postoperative administration group), and (3) not administered (no administration group). The IOP was measured using a rebound tonometer 1 hour preoperatively, upon completion of surgery, and at 1, 3, 5, 7, and 24 hours postoperatively.RESULTS:
The study comprised 96 patients (96 eyes). The mean IOP increased at 3, 5, and 7 hours postoperatively in all groups. At 1 hour and 3 hours postoperatively, the IOP was significantly lower in the preoperative administration group than in the postoperative group and no administration group (P ≤ .001). At 5, 7, and 24 hours postoperatively, the IOP was significantly lower in the preoperative group and postoperative administration group than in the no administration group (P ≤. 045). An IOP spike higher than 25 mm Hg occurred less frequently in the preoperative administration group than in the postoperative administration group and the no administration group (P = .038).CONCLUSIONS:
Intraocular pressure increased at 3, 5, and 7 hours after cataract surgery in eyes with PXF syndrome. Oral acetazolamide administered 1 hour preoperatively reduced the IOP elevation throughout the 24-hour follow-up; acetazolamide administered 3 hours postoperatively reduced the elevation at 5 hours postoperatively and thereafter.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Inhibidores de Anhidrasa Carbónica
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Hipertensión Ocular
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Síndrome de Exfoliación
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Facoemulsificación
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Presión Intraocular
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Acetazolamida
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Observational_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Año:
2018
Tipo del documento:
Article