Analysis of hpf1 expression and function in early embryonic development of zebrafish.
Dev Genes Evol
; 228(2): 141-147, 2018 03.
Article
en En
| MEDLINE
| ID: mdl-29549427
ABSTRACT
About 70% of zebrafish (Danio rerio) genes are orthologues of the human's, which are of great interests, but still largely unknown for their functions. Recently, a report on human histone PARylation factor 1 (HPF1/C4orf27) showed that it is involved in DNA damage response along with poly (ADP-ribose) polymerase 1 (PARP1). However, its function in living organism remains unclear. Given that zebrafish has showed its values in modeling human diseases and physiology, we characterized a zebrafish homolog of human HPF1 by sequence alignment. We also analyzed its expression pattern during early development and among adult tissues. Furthermore, knocking down hpf1 by morpholinos affected zebrafish early development. Our work provides a novel clue for the mechanism of genome stability and early embryogenesis.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Pez Cebra
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Proteínas Nucleares
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Proteínas Portadoras
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Regulación del Desarrollo de la Expresión Génica
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Modelos Animales
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Embrión no Mamífero
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Poli(ADP-Ribosa) Polimerasa-1
Tipo de estudio:
Prognostic_studies
Límite:
Animals
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Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article