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Analysis of hpf1 expression and function in early embryonic development of zebrafish.
Zhang, Zhen; Sun, Hongwei; Chen, Yu; Cao, Tianqi; Songyang, Zhou; Huang, Junjiu; Huang, Yan.
  • Zhang Z; Key Laboratory of Gene Engineering of the Ministry of Education, Institute of Healthy Aging Research and State Key Laboratory of Biocontrol, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.
  • Sun H; Key Laboratory of Gene Engineering of the Ministry of Education, Institute of Healthy Aging Research and State Key Laboratory of Biocontrol, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.
  • Chen Y; Key Laboratory of Gene Engineering of the Ministry of Education, Institute of Healthy Aging Research and State Key Laboratory of Biocontrol, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.
  • Cao T; Key Laboratory of Gene Engineering of the Ministry of Education, Institute of Healthy Aging Research and State Key Laboratory of Biocontrol, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.
  • Songyang Z; Key Laboratory of Gene Engineering of the Ministry of Education, Institute of Healthy Aging Research and State Key Laboratory of Biocontrol, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.
  • Huang J; Key Laboratory of Gene Engineering of the Ministry of Education, Institute of Healthy Aging Research and State Key Laboratory of Biocontrol, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.
  • Huang Y; Key Laboratory of Reproductive Medicine of Guangdong Province, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Dev Genes Evol ; 228(2): 141-147, 2018 03.
Article en En | MEDLINE | ID: mdl-29549427
ABSTRACT
About 70% of zebrafish (Danio rerio) genes are orthologues of the human's, which are of great interests, but still largely unknown for their functions. Recently, a report on human histone PARylation factor 1 (HPF1/C4orf27) showed that it is involved in DNA damage response along with poly (ADP-ribose) polymerase 1 (PARP1). However, its function in living organism remains unclear. Given that zebrafish has showed its values in modeling human diseases and physiology, we characterized a zebrafish homolog of human HPF1 by sequence alignment. We also analyzed its expression pattern during early development and among adult tissues. Furthermore, knocking down hpf1 by morpholinos affected zebrafish early development. Our work provides a novel clue for the mechanism of genome stability and early embryogenesis.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pez Cebra / Proteínas Nucleares / Proteínas Portadoras / Regulación del Desarrollo de la Expresión Génica / Modelos Animales / Embrión no Mamífero / Poli(ADP-Ribosa) Polimerasa-1 Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pez Cebra / Proteínas Nucleares / Proteínas Portadoras / Regulación del Desarrollo de la Expresión Génica / Modelos Animales / Embrión no Mamífero / Poli(ADP-Ribosa) Polimerasa-1 Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article