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In vitro efficacy of ARQ 092, an allosteric AKT inhibitor, on primary fibroblast cells derived from patients with PIK3CA-related overgrowth spectrum (PROS).
Ranieri, C; Di Tommaso, S; Loconte, D C; Grossi, V; Sanese, P; Bagnulo, R; Susca, F C; Forte, G; Peserico, A; De Luisi, A; Bartuli, A; Selicorni, A; Melis, D; Lerone, M; Praticò, A D; Abbadessa, G; Yu, Y; Schwartz, B; Ruggieri, Martino; Simone, Cristiano; Resta, Nicoletta.
  • Ranieri C; Division of Medical Genetics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari "Aldo Moro", Piazza G. Cesare, 11, Bari, Italy.
  • Di Tommaso S; Division of Medical Genetics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari "Aldo Moro", Piazza G. Cesare, 11, Bari, Italy.
  • Loconte DC; Division of Medical Genetics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari "Aldo Moro", Piazza G. Cesare, 11, Bari, Italy.
  • Grossi V; Division of Medical Genetics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari "Aldo Moro", Piazza G. Cesare, 11, Bari, Italy.
  • Sanese P; Division of Medical Genetics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari "Aldo Moro", Piazza G. Cesare, 11, Bari, Italy.
  • Bagnulo R; Division of Medical Genetics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari "Aldo Moro", Piazza G. Cesare, 11, Bari, Italy.
  • Susca FC; Division of Medical Genetics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari "Aldo Moro", Piazza G. Cesare, 11, Bari, Italy.
  • Forte G; Medical Genetics, National Institute for Gastroenterology, IRCCS 'S. de Bellis', Piazza G. Cesare, 11, Castellana Grotte, Bari, Italy.
  • Peserico A; Division of Medical Genetics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari "Aldo Moro", Piazza G. Cesare, 11, Bari, Italy.
  • De Luisi A; Division of Medical Genetics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari "Aldo Moro", Piazza G. Cesare, 11, Bari, Italy.
  • Bartuli A; Unit of Rare Diseases and Medical Genetics, Bambino Gesù Children's Hospital, Rome, Italy.
  • Selicorni A; Unit of Pediatrics, Presidio S. Fermo, ASST Lariana, Como, Italy.
  • Melis D; Department of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy.
  • Lerone M; Unit of Medical Genetics, Giannina Gaslini Institute, Genoa, Italy.
  • Praticò AD; Unit of Rare Diseases of the Nervous System in Childhood, Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, Via Santa Sofia, 78, 95124, Catania, Italy.
  • Abbadessa G; Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK.
  • Yu Y; Clinical Development, Translational Research, Medical Affairs, ArQule, Inc., Burlington, MA, USA.
  • Schwartz B; Translational Research, ArQule, Inc., Burlington, MA, USA.
  • Ruggieri M; Clinical Development, Translational Research, Medical Affairs, ArQule, Inc., Burlington, MA, USA.
  • Simone C; Unit of Rare Diseases of the Nervous System in Childhood, Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, Via Santa Sofia, 78, 95124, Catania, Italy. m.ruggieri@unict.it.
  • Resta N; Division of Medical Genetics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari "Aldo Moro", Piazza G. Cesare, 11, Bari, Italy. cristiano.simone@uniba.it.
Neurogenetics ; 19(2): 77-91, 2018 05.
Article en En | MEDLINE | ID: mdl-29549527

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas c-akt / Fosfatidilinositol 3-Quinasa Clase I / Fibroblastos / Trastornos del Crecimiento / Aminopiridinas / Imidazoles Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Año: 2018 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas c-akt / Fosfatidilinositol 3-Quinasa Clase I / Fibroblastos / Trastornos del Crecimiento / Aminopiridinas / Imidazoles Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Año: 2018 Tipo del documento: Article