Upregulation of microRNA-320 decreases the risk of developing steroid-induced avascular necrosis of femoral head by inhibiting CYP1A2 both in vivo and in vitro.

Wei, Ji-Hua; Luo, Qun-Qiang; Tang, Yu-Jin; Chen, Ji-Xia; Huang, Chun-Lan; Lu, Ding-Gui; Tang, Qian-Li

Wei, Ji-Hua; Luo, Qun-Qiang; Tang, Yu-Jin; Chen, Ji-Xia; Huang, Chun-Lan; Lu, Ding-Gui; Tang, Qian-Li.

Wei JH; Jinan University, Guangzhou 510632, PR China; Department of Orthopedics, the Affiliated Hospital of Youjiang Medical University for Nationality, Baise 533000, PR China.
Luo QQ; Department of Orthopedics, the Affiliated Hospital of Youjiang Medical University for Nationality, Baise 533000, PR China.
Tang YJ; Department of Orthopedics, the Affiliated Hospital of Youjiang Medical University for Nationality, Baise 533000, PR China.
Chen JX; Department of Orthopedics, the Affiliated Hospital of Youjiang Medical University for Nationality, Baise 533000, PR China.
Huang CL; Department of Orthopedics, the Affiliated Hospital of Youjiang Medical University for Nationality, Baise 533000, PR China.
Lu DG; Department of Orthopedics, the Affiliated Hospital of Youjiang Medical University for Nationality, Baise 533000, PR China.
Tang QL; Key Laboratory of High Incidence of Disease Prevention in the West of Guangxi, Youjiang Medical University for Nationality, Baise 533000, PR China. Electronic address: tangqianli_pr@163.com.

Gene ; 660: 136-144, 2018 Jun 20.

Article en En | MEDLINE | ID: mdl-29551500

Asunto(s)

Citocromo P-450 CYP1A2/metabolismo; Fracturas del Cuello Femoral/metabolismo; Necrosis de la Cabeza Femoral/metabolismo; MicroARNs/biosíntesis; Regulación hacia Arriba; Animales; Citocromo P-450 CYP1A2/genética; Femenino; Fracturas del Cuello Femoral/genética; Fracturas del Cuello Femoral/patología; Necrosis de la Cabeza Femoral/genética; Necrosis de la Cabeza Femoral/patología; Necrosis de la Cabeza Femoral/prevención & control; Humanos; Masculino; MicroARNs/genética; Ratas; Ratas Sprague-Dawley

Palabras clave

CYP1A2; MicroRNA-320; Rat model; Steroid-induced avascular necrosis of femoral head

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Regulación hacia Arriba / Citocromo P-450 CYP1A2 / MicroARNs / Fracturas del Cuello Femoral / Necrosis de la Cabeza Femoral Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans / Male Idioma: En Año: 2018 Tipo del documento: Article

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