Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2).
Cell Mol Gastroenterol Hepatol
; 5(3): 367-398, 2018 Mar.
Article
en En
| MEDLINE
| ID: mdl-29552625
ACACA, acetyl-CoA carboxylase alpha; ACLY, ATP citrate lyase; ACOT7, acetyl-CoA thioesterase 7; ACOX2, acetyl-CoA oxidase 2; ADRP, adipose differentiation-related protein; AP-1, activator protein 1; ATF4, activating transcription factor-4; ATF6, activating transcription factor-6; ApoB, apolipoprotein B; BCL-2, B-cell lymphoma; BIP, binding immunoglobulin protein; C/EBP, CCAAT/enhancer-binding protein; CAT, catalase; CD36, cluster of differentiation 36; CDDO, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid; CES1G, carboxylesterase 1g; CHOP, C/EBP homologous protein; COL1A1, collagen, type I, alpha-1; COX2, cyclooxygenase-2; CPT1A, carnitine palmitoyltransferase 1a; ChREBP, carbohydrate-responsive element-binding protein; DGAT2, diacylglycerol acyltransferase-2; DMSO, dimethyl sulfoxide; ER, endoplasmic reticulum; FASN, fatty acid synthase; FXR, farnesoid X receptor; GCLC, glutamate-cysteine ligase catalytic; GCLM, glutamate-cysteine ligase modifier; GPX2, glutathione peroxidase-2; GSH, reduced glutathione; GSSG, oxidized glutathione; GSTA4, glutathione S-transferase Alpha-4; GSTM1, glutathione S-transferase Mu-1; GTT, glucose tolerance test; H&E, hematoxylin and eosin; HF, high-fat; HF30Fr, high-fat diet with 30% fructose in drinking water; HF55Fr, high-fat diet with 55% fructose in drinking water; HFFr, high-fat diet with fructose in drinking water; HMOX1, heme oxygenase-1; IKK, IκB kinase; IRE1α, inositol requiring kinase-1α; ITT, insulin tolerance test; IκB, inhibitor of NF-κB; JNK1, c-Jun N-terminal kinase 1; Keap1, Kelch-like ECH-associated protein-1; LXRα, liver X receptor α; MCD, methionine- and choline-deficient; MCP-1, monocyte chemotactic protein-1; MGPAT, mitochondrial glycerol-3-phosphate acetyltransferase; MPO, myeloperoxidase; MTTP, microsomal triglyceride transfer protein; NAFLD, non-alcoholic fatty liver disease; NAS, NAFLD activity score; NASH; NASH, nonalcoholic steatohepatitis; NF-κB, nuclear factor-κB; NOS2, nitric oxide synthase-2; NQO1, NAD(P)H:quinone oxidoreductase 1; Nrf2; Nrf2, NF-E2 p45-related factor 2; PARP, poly ADP ribose polymerase; PCR, polymerase chain reaction; PDI, protein disulfide isomerase; PERK, PRK-like endoplasmic reticulum kinase; PPARα, peroxisome proliferator-activated receptor α; PPARγ, peroxisome proliferator-activated receptor γ; PRDX6, peroxiredoxin 6; PTGR1, prostaglandin reductase-1; PTT, pyruvate tolerance test; RC, regular chow; SCAD, short-chain acyl-CoA dehydrogenase; SCD1, stearoyl-CoA desaturase-1; SFN, sulforaphane; SHP, small heterodimer partner; SLC7A11, solute carrier family 7 member 11; SREBP-1c, sterol regulatory element-binding protein-1c; TBE-31; TGFß, transforming growth factor beta-1; TNF-α, tumor necrosis factor-α; TXN1, thioredoxin-1; TXNRD1, thioredoxin reductase-1; UPR, unfolded protein response; XBP1, X-box binding protein-1; eIf2α, eukaryotic translation initiation factor 2A; p58IPK, p58 inhibitor of the PKR kinase; qRT-PCR, quantitative reverse transcriptase PCR; α-SMA, alpha smooth muscle actin
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