Predictors of isoniazid preventive therapy completion among adults newly diagnosed with HIV in rural Malawi.
Int J Tuberc Lung Dis
; 22(4): 371-377, 2018 04 01.
Article
en En
| MEDLINE
| ID: mdl-29562983
ABSTRACT
SETTING:
To reduce the risk of tuberculosis (TB) among individuals with human immunodeficiency virus (HIV) infection, the World Health Organization recommends at least 6 months of isoniazid preventive therapy (IPT). Completion of IPT remains a major challenge in resource-limited settings.OBJECTIVE:
To evaluate predictors of IPT completion in individuals newly diagnosed with HIV.DESIGN:
Predictors of IPT completion among adults newly diagnosed with HIV in rural Malawi were evaluated using a multilevel logistic regression model.RESULTS:
Of 974 participants who screened negative for active TB and were started on IPT, 732 (75%) completed treatment. Only one IPT-eligible individual refused treatment. Participants who were aged <25 years (compared with those aged î¶45 years, adjusted OR [aOR] 0.33, 95%CI 0.18-0.60) and male (compared to non-pregnant females, aOR 0.57, 95%CI 0.37-0.88) had lower odds of IPT completion.CONCLUSION:
IPT provision at the time of initial HIV diagnosis was highly acceptable in rural Malawi; three quarters of those who initiated IPT successfully completed therapy. We observed lower odds of completion among males and among female participants aged <25 years. Additional efforts may be needed to ensure IPT completion among males and young females who have recently been diagnosed with HIV.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tuberculosis
/
Infecciones por VIH
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Cumplimiento de la Medicación
/
Isoniazida
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Antituberculosos
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
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Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
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Middle aged
/
Pregnancy
País como asunto:
Africa
Idioma:
En
Año:
2018
Tipo del documento:
Article