Long-term follow-up of Chagas heart disease patients receiving an implantable cardioverter-defibrillator for secondary prevention.
Pacing Clin Electrophysiol
; 41(6): 583-588, 2018 06.
Article
en En
| MEDLINE
| ID: mdl-29578582
ABSTRACT
BACKGROUND:
Chagas heart disease (CHD) is a dilated cardiomyopathy characterized by malignant ventricular arrhythmias and increased risk of sudden cardiac death (SCD). Much controversy exists concerning the efficacy of implantable cardioverter-defibrillator (ICDs) in CHD because of mixed results observed. We report our long-term experience with ICDs for secondary prevention in CHD, with the specific aim of assessing the results in groups with preserved or depressed global left ventricular function.METHODS:
111 patients (75 males; 60 ± 12 years) were followed for 1,948 ± 1,275 days after ICD. Time to death was the primary outcome; LVEF ≤ 45% the exposure; and age, gender, and ICD therapy delivery the potential confounders. We used time-to-event methods and Cox proportional models for analysis, censoring observations at time of death or at 5-year follow-up in survivors.RESULTS:
Seventy-two percent of the patients presented at least one sustained ventricular arrhythmia requiring appropriate therapy, and only three patients received inappropriate therapy. Death occurred in 50 (45%) patients, with an annual mortality rate of 8.4%, mostly due to refractory heart failure or noncardiac causes. Unadjusted survival rates were significantly distinct between patients with left ventricular ejection fraction (LVEF) ≤ 45% (26 deaths), 50.5% (95% confidence interval [CI] 36.2%-63.2%) when compared to patients with LVEF > 45% (10 deaths), 77.6% (95% CI 62.3%-87.3%, P < 0.01). After adjusting for confounders, low LVEF (hazard ratio [HR] 5.2, 95% CI 2.3-11.6), age (HR 1.04, 95% CI 1.01-1.07), and female gender (HR 3.97, 95% CI 1.85-8.54) were independently associated with the outcome.CONCLUSIONS:
ICDs successfully aborted life-threatening arrhythmias in CHD patients. Impaired left ventricular function predicted higher mortality in CHD patients with an ICD for secondary prevention of SCD.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cardiomiopatía Chagásica
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Muerte Súbita Cardíaca
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Taquicardia Ventricular
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Desfibriladores Implantables
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Prevención Secundaria
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2018
Tipo del documento:
Article