Characterization of the Neutralizing Antibody Response in a Case of Genetically Linked HIV Superinfection.
J Infect Dis
; 217(10): 1530-1534, 2018 04 23.
Article
en En
| MEDLINE
| ID: mdl-29579256
ABSTRACT
This report describes the identification of a genetically confirmed linked heterosexual human immunodeficiency virus (HIV) superinfection (HIV-SI) in a woman with chronic HIV infection who acquired a second strain of the virus from her husband. Serum neutralizing antibody (NAb) responses against their homologous and heterologous viruses, including the superinfecting strain, in the woman and her husband were examined before and after onset of HIV-SI. The woman displayed a moderately potent and broad anti-HIV NAb response prior to superinfection but did not possess NAb activity against the superinfecting strain. This case highlights the unique potential of linked HIV-SI studies to examine natural protection from HIV infection.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Anticuerpos Anti-VIH
/
Sobreinfección
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Infecciones por VIH
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VIH-1
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Anticuerpos Neutralizantes
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Formación de Anticuerpos
Tipo de estudio:
Prognostic_studies
Límite:
Female
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Humans
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Male
Idioma:
En
Año:
2018
Tipo del documento:
Article