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Long non-coding RNA-CTD-2108O9.1 represses breast cancer metastasis by influencing leukemia inhibitory factor receptor.
Wang, Mozhi; Wang, Mengshen; Wang, Zhenning; Yu, Xueting; Song, Yongxi; Wang, Chong; Xu, Yujie; Wei, Fengheng; Zhao, Yi; Xu, Yingying.
  • Wang M; Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Wang M; Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Wang Z; Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang, China.
  • Yu X; Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Song Y; Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang, China.
  • Wang C; Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Xu Y; Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Wei F; Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Zhao Y; Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Xu Y; Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
Cancer Sci ; 109(6): 1764-1774, 2018 Jun.
Article en En | MEDLINE | ID: mdl-29603493
ABSTRACT
Breast cancer (BC) is an aggressive malignant disease in women worldwide with a high tendency to metastasize. However, important biomarkers for BC metastasis remain largely undefined. In the present study, we identified that long non-coding RNA-CTD-2108O9.1 is downregulated in BC tissues and cells and acts as a metastatic inhibitor of BC. Mechanistic investigation determined that lncRNA-CTD-2108O9.1 represses metastasis by targeting leukemia inhibitory factor receptor (LIFR), which is designated as a metastasis suppressor in BC. Our study characterizes a significant tumor suppressor active in BC metastasis repression through the known metastasis inhibitor LIFR.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Regulación Neoplásica de la Expresión Génica / Receptores OSM-LIF / ARN Largo no Codificante Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Middle aged Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
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XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Regulación Neoplásica de la Expresión Génica / Receptores OSM-LIF / ARN Largo no Codificante Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Middle aged Idioma: En Año: 2018 Tipo del documento: Article