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Growth morbidity in extremely low birth weight survivors of necrotizing enterocolitis at discharge and two-year follow-up.
Hong, Charles R; Fullerton, Brenna S; Mercier, Charles E; Morrow, Kate A; Edwards, Erika M; Ferrelli, Karla R; Soll, Roger F; Modi, Biren P; Horbar, Jeffrey D; Jaksic, Tom.
  • Hong CR; Center for Advanced Intestinal Rehabilitation, Department of Surgery, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
  • Fullerton BS; Center for Advanced Intestinal Rehabilitation, Department of Surgery, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
  • Mercier CE; University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA.
  • Morrow KA; Vermont Oxford Network, 33 Kilburn Street, Burlington, VT 05401, USA.
  • Edwards EM; University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA; Vermont Oxford Network, 33 Kilburn Street, Burlington, VT 05401, USA.
  • Ferrelli KR; Vermont Oxford Network, 33 Kilburn Street, Burlington, VT 05401, USA.
  • Soll RF; University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA; Vermont Oxford Network, 33 Kilburn Street, Burlington, VT 05401, USA.
  • Modi BP; Center for Advanced Intestinal Rehabilitation, Department of Surgery, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
  • Horbar JD; University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA; Vermont Oxford Network, 33 Kilburn Street, Burlington, VT 05401, USA.
  • Jaksic T; Center for Advanced Intestinal Rehabilitation, Department of Surgery, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address: tom.jaksic@childrens.harvard.edu.
J Pediatr Surg ; 53(6): 1197-1202, 2018 Jun.
Article en En | MEDLINE | ID: mdl-29627178
ABSTRACT

PURPOSE:

The purpose of this study was to examine postnatal growth outcomes and predictors of growth failure at 18-24months corrected age among extremely low birth weight (ELBW) survivors of necrotizing enterocolitis (NEC) compared to survivors without NEC.

METHODS:

Data were collected prospectively on ELBW (22-27weeks gestation or 401-1000g birth weight) infants born 2000-2013 at 46 centers participating in the Vermont Oxford Network follow-up project. Severe growth failure was defined as <3rd percentile weight-for-age.

RESULTS:

There were 9171 evaluated infants without NEC, 416 with medical NEC, and 462 with surgical NEC. Rates of severe growth failure at discharge were higher among infants with medical NEC (56%) and surgical NEC (61%), compared to those without NEC (36%). At 18-24months follow-up, rates of severe growth failure decreased and were similar between without NEC (24%), medical NEC (24%), and surgical NEC (28%). On multivariable analysis, small for gestational age, chronic lung disease, severe intraventricular hemorrhage or cystic periventricular leukomalacia, severe growth failure at discharge, and postdischarge tube feeding predicted <3rd percentile weight-for-age at follow-up.

CONCLUSIONS:

ELBW survivors of NEC have higher rates of severe growth failure at discharge. While NEC is not associated with severe growth failure at follow-up, one quarter of ELBW infants have severe growth failure at 18-24months. TYPE OF STUDY Prognosis study. LEVEL OF EVIDENCE II.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enterocolitis Necrotizante / Recien Nacido con Peso al Nacer Extremadamente Bajo / Trastornos del Crecimiento / Enfermedades del Prematuro Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Infant / Male / Newborn Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enterocolitis Necrotizante / Recien Nacido con Peso al Nacer Extremadamente Bajo / Trastornos del Crecimiento / Enfermedades del Prematuro Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Infant / Male / Newborn Idioma: En Año: 2018 Tipo del documento: Article