Visceral adipose tissue-derived serine protease inhibitor accelerates cholesterol efflux by up-regulating ABCA1 expression via the NF-κB/miR-33a pathway in THP-1 macropahge-derived foam cells.
Biochem Biophys Res Commun
; 500(2): 318-324, 2018 06 02.
Article
en En
| MEDLINE
| ID: mdl-29653102
ABSTRACT
Atherosclerosis is a dyslipidemia disease characterized by foam cell formation driven by the accumulation of lipids. Visceral adipose tissue-derived serine protease inhibitor (vaspin) is known to suppress the development of atherosclerosis via its anti-inflammatory properties, but it is not yet known whether vaspin affects cholesterol efflux in THP-1 macrophage-derived foam cells. Here, we investigated the effects of vaspin on ABCA1 expression and cholesterol efflux, and further explored the underlying mechanism. We found that vaspin decreased miR-33a levels, which in turn increased ABCA1 expression and cholesteorl efflux. We also found that inhibition of NF-κB reduced miR-33a expression and vaspin suppressed LPS-mediated NF-κB phosphorylation. Our findings suggest that vaspin is not only a regular of inflammasion but also a promoter of cholesterol efflux.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Serpinas
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Regulación hacia Arriba
/
Colesterol
/
FN-kappa B
/
MicroARNs
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Grasa Intraabdominal
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Transportador 1 de Casete de Unión a ATP
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Células Espumosas
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Macrófagos
Límite:
Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article