Immune senescence, epigenetics and autoimmunity.
Clin Immunol
; 196: 59-63, 2018 11.
Article
en En
| MEDLINE
| ID: mdl-29654845
ABSTRACT
Aging of the immune system in humans and animals is characterized by a decline in both adaptive and innate immune responses. Paradoxically, aging is also associated with a state of chronic inflammation ("inflammaging") and an increased likelihood of developing autoimmune diseases. Epigenetic changes in non-dividing and dividing cells, including immune cells, due to environmental factors contribute to the inflammation and autoimmunity that characterize both the state and diseases of aging. Here, we review the epigenetic mechanisms involved in the development of immune senescence and autoimmunity in old age.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Autoinmunes
/
Envejecimiento
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Autoinmunidad
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Epigénesis Genética
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Inmunosenescencia
Límite:
Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article