Effect of 12-month treatment with metformin and/or oral contraceptives on health-related quality of life in polycystic ovary syndrome.
Gynecol Endocrinol
; 34(10): 859-863, 2018 Oct.
Article
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| MEDLINE
| ID: mdl-29658344
ABSTRACT
Health-related quality of life (HRQoL) is impaired in polycystic ovary syndrome (PCOS), but the effect of treatment with metformin (M) and/or oral contraceptives (OCP) is undetermined. To assess changes in HRQoL during 12-month randomized treatment with M, OCP or M + OCP in PCOS. Ninety women with PCOS were randomized to treatment with M, OCP or M + OCP. HRQoL was evaluated by a PCOS-specific visual analog scale (PCOS-VAS) regarding 1 Facial hair, 2 Body hair, 3 Acne, 4 Irregular menses, 5 Weight and 6 PCOS in general, and Short Form 36 (SF-36). PCOS-VAS1(facial hair) improved during treatment with OCP (n = 23) compared to M (n = 19), and during M + OCP (n = 23) compared to M treatment, whereas changes in PCOS-VAS2-6 and SF-36 scores were comparable between the three medical intervention groups. Pooled data (n = 65) showed improved PCOS-VAS scores during treatment (all p < .05), but changes in PCOS-VAS were unassociated with changes in BMI or FG-scores despite significant weight-loss during treatment with M (-3.0 kg (-10.3; 0.6)) and M + OCP (-1.9 kg (-4.9; 0.1)) and decreased FG-score during M + OCP treatment (median (quartiles)). PCOS-VAS scores improved significantly and to the same extent during treatment with M, OCP or M + OCP.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Síndrome del Ovario Poliquístico
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Calidad de Vida
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Anticonceptivos Hormonales Orales
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Hipoglucemiantes
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Metformina
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
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Adult
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Female
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Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article