Dual functionality of ß-tryptase protomers as both proteases and cofactors in the active tetramer.

Maun, Henry R; Liu, Peter S; Franke, Yvonne; Eigenbrot, Charles; Forrest, William F; Schwartz, Lawrence B; Lazarus, Robert A

Maun, Henry R; Liu, Peter S; Franke, Yvonne; Eigenbrot, Charles; Forrest, William F; Schwartz, Lawrence B; Lazarus, Robert A.

Maun HR; From the Departments of Early Discovery Biochemistry.
Liu PS; Microchemistry, Proteomics and Lipidomics.
Franke Y; Biomolecular Resources.
Eigenbrot C; Structural Biology, and.
Forrest WF; Bioinformatics and Computational Biology, Genentech, Inc., South San Francisco, California 94080 and.
Schwartz LB; the Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia 23298.
Lazarus RA; From the Departments of Early Discovery Biochemistry, lazarus.bob@gene.com.

J Biol Chem ; 293(25): 9614-9628, 2018 06 22.

Article en En | MEDLINE | ID: mdl-29661938

Asunto(s)

Heparina/metabolismo; Péptido Hidrolasas/metabolismo; Regiones Promotoras Genéticas; Multimerización de Proteína; Triptasas/genética; Triptasas/metabolismo; Regulación Alostérica; Cristalografía por Rayos X; Humanos; Modelos Moleculares; Mutagénesis Sitio-Dirigida; Mutación; Conformación Proteica; Subunidades de Proteína; Triptasas/química

Palabras clave

allosteric regulation; enzyme mechanism; heparin-binding protein; protein engineering; proteinprotein interaction; serine protease; tetramerization; tryptase

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Péptido Hidrolasas / Heparina / Regiones Promotoras Genéticas / Triptasas / Multimerización de Proteína Límite: Humans Idioma: En Año: 2018 Tipo del documento: Article

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