The photodynamic activity of 131-[2'-(2-pyridyl)ethylamine] chlorin e6 photosensitizer in human esophageal cancer.
Bioorg Med Chem Lett
; 28(10): 1785-1791, 2018 06 01.
Article
en En
| MEDLINE
| ID: mdl-29673979
ABSTRACT
A novel 131-pyridine substituted chlorin e6 derivative (Chlorin A) was synthesized. It has characteristic long wavelength absorption at 664â¯nm and the emission wavelength at 667â¯nm. The generation rate of singlet oxygen of this compound is higher than Temoporfin. In vitro, Chlorin A showed higher phototoxicity against the human esophageal cancer cells than Temoporfin while with lower dark-toxicity. Its accumulation effect in mitochondria, lysosomes and endoplasmic reticulum was traced in subcellular localization tests. In flow cytometry obvious apoptosis cells were observed after 2â¯h irradiation. Significant in vivo photodynamic anti-tumor efficacy was also exhibited on mice bearing esophageal cancer. So Chlorin A could be suggested as a promising anti-tumor drug candidate in photodynamic therapy.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fotoquimioterapia
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Porfirinas
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Piridinas
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Neoplasias Esofágicas
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Fármacos Fotosensibilizantes
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Antineoplásicos
Límite:
Animals
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Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article