Spikes might precede seizures and predict epilepsy in children with Sturge-Weber syndrome: A pilot study.
Epilepsy Res
; 143: 75-78, 2018 07.
Article
en En
| MEDLINE
| ID: mdl-29674168
ABSTRACT
PURPOSE:
Sturge-Weber syndrome (SWS) is a neurocutaneous disorder characterized by a facial port-wine stain, a glaucoma, and a leptomeningeal angioma. Epilepsy occurs in more than 75% of affected children, and seizures occurring in the first year of life are associated with a poor neurological prognosis. The aim of this study was to identify possible predictive markers of epilepsy on electroencephalogram (EEG) performed prior to seizure onset in children with SWS.METHODS:
This study included children with a diagnosis of SWS who had an EEG performed prior to seizure onset. Patients who did not develop epilepsy had a minimum follow-up of 3-years. We compared EEG characteristics of patients who developed epilepsy with patients who did not develop epilepsy by the time of their follow-up.RESULTS:
Eleven children were included in this study. EEG was performed at the median age of 2.1 months (range 1.0-22.1). Six children developed seizures with a time interval between EEG and seizure onset ranging from 2â¯days to 21 months. EEG background activity was asymmetric in 8 patients, 5 of whom later developed epilepsy. Focal interictal spikes or sharp waves were exclusively recorded in patients who developed later epilepsy (4 out of 6). One of these patients had a supposed false positive EEG as he did not developed epilepsy until 21 months later and one patient had a false negative EEG with seizures occurring 2â¯days after a normal EEG.CONCLUSION:
Spikes on EEG might be a useful marker to identify patients with SWS at risk of developing epilepsy. Their predictive value should be assessed in larger prospective studies.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Convulsiones
/
Encéfalo
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Síndrome de Sturge-Weber
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Electroencefalografía
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Epilepsia
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Female
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Humans
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Infant
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Male
Idioma:
En
Año:
2018
Tipo del documento:
Article