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An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance.
Bester, Assaf C; Lee, Jonathan D; Chavez, Alejandro; Lee, Yu-Ru; Nachmani, Daphna; Vora, Suhani; Victor, Joshua; Sauvageau, Martin; Monteleone, Emanuele; Rinn, John L; Provero, Paolo; Church, George M; Clohessy, John G; Pandolfi, Pier Paolo.
  • Bester AC; Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.
  • Lee JD; Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.
  • Chavez A; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA; Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia Un
  • Lee YR; Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.
  • Nachmani D; Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.
  • Vora S; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.
  • Victor J; Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.
  • Sauvageau M; Department of Stem Cell and Regenerative Biology, Harvard University, The Broad Institute of MIT and Harvard, Cambridge, MA, USA; Functional Genomics and Noncoding RNAs Research Unit, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC, Canada; Department of Biochemistry and Molecular
  • Monteleone E; Department of Molecular Biotechnology and Health Sciences, and GenoBiToUS, Genomics and Bioinformatics Service, University of Turin, Turin, Italy.
  • Rinn JL; Department of Stem Cell and Regenerative Biology, Harvard University, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Provero P; Department of Molecular Biotechnology and Health Sciences, and GenoBiToUS, Genomics and Bioinformatics Service, University of Turin, Turin, Italy; Center for Translational Genomics and Bioinformatics, San Raffaele Scientific Institute IRCCS, Milan, Italy.
  • Church GM; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.
  • Clohessy JG; Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA; Preclinical Murine Pharmacogenetics Facility and Mou
  • Pandolfi PP; Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA. Electronic address: ppandolf@bidmc.harvard.edu.
Cell ; 173(3): 649-664.e20, 2018 04 19.
Article en En | MEDLINE | ID: mdl-29677511
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Genoma Humano / Resistencia a Antineoplásicos / ARN Largo no Codificante / Sistemas CRISPR-Cas Límite: Animals / Female / Humans / Male Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Genoma Humano / Resistencia a Antineoplásicos / ARN Largo no Codificante / Sistemas CRISPR-Cas Límite: Animals / Female / Humans / Male Idioma: En Año: 2018 Tipo del documento: Article