Single-Cell RNA-Seq Reveals Transcriptional Heterogeneity in Latent and Reactivated HIV-Infected Cells.
Cell Rep
; 23(4): 942-950, 2018 04 24.
Article
en En
| MEDLINE
| ID: mdl-29694901
ABSTRACT
Despite effective treatment, HIV can persist in latent reservoirs, which represent a major obstacle toward HIV eradication. Targeting and reactivating latent cells is challenging due to the heterogeneous nature of HIV-infected cells. Here, we used a primary model of HIV latency and single-cell RNA sequencing to characterize transcriptional heterogeneity during HIV latency and reactivation. Our analysis identified transcriptional programs leading to successful reactivation of HIV expression.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Activación Viral
/
Regulación Viral de la Expresión Génica
/
Infecciones por VIH
/
VIH-1
/
Análisis de Secuencia de ARN
/
Latencia del Virus
Límite:
Female
/
Humans
/
Male
Idioma:
En
Año:
2018
Tipo del documento:
Article