Perfluoroalkyl substances in umbilical cord serum and gestational and postnatal growth in a Chinese birth cohort.
Environ Int
; 116: 197-205, 2018 07.
Article
en En
| MEDLINE
| ID: mdl-29698896
ABSTRACT
Although animal studies have found that perfluoroalkyl substances (PFASs) affect gestational and postnatal growth, the epidemiological findings are limited and not in agreement. We explored the associations of PFAS concentrations in umbilical cord blood with gestational and postnatal growth in China. Three hundred thirty-seven singleton newborns and their mothers were recruited from November 2013 to December 2015 in Zhoukou City, China. Umbilical cord blood was collected to measure eleven PFASs by liquid chromatography-mass spectrometry. The index of gestational and postnatal growth contained fetal weight, length, and head circumference. These were obtained at birth and at the follow-up investigation (mean 19â¯months). Exposed to higher perfluorooctanoic acid (PFOA) were connected with reduced length at birth (p for trendâ¯=â¯0.01) and decreased postnatal weight (ßâ¯=â¯-429.2â¯g; 95% CI -858.4, -0.121 for 2nd VS. 1st). Exposed to perfluoroundecanoic acid (PFUdA) were positively associated with indications of gestational growth and postnatal growth (p for trendâ¯=â¯0.02 for birth length; p for trendâ¯=â¯0.04 for postnatal length). Exposed to higher perfluorododecanoic acid (PFDoA) were associated with lower birth weight (ßâ¯=â¯-122.9â¯g, 95% CI -244.7 to -1.2 for 2nd VS. 1st), but higher postnatal length (p for trendâ¯=â¯0.03). Neonates in the highest exposure group of per-fluorohexanesulfonate (PFHxS) showed decreased birth length (ßâ¯=â¯-0.33â¯cm, 95% CI -0.68 to -0.01, for 2nd VS. 1st), but increased postnatal head circumference (p for trendâ¯=â¯0.04). Increased PFOA concentrations was associated with shorter birth length only in girls (p for trendâ¯=â¯0.04), suggesting that the effect of PFASs on gestational growth were different between boys and girls. In utero exposure to PFASs may affect gestational and postnatal growth.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Peso al Nacer
/
Desarrollo Infantil
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Exposición Materna
/
Sangre Fetal
/
Fluorocarburos
Tipo de estudio:
Etiology_studies
/
Incidence_studies
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Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Newborn
País como asunto:
Asia
Idioma:
En
Año:
2018
Tipo del documento:
Article