An antimicrobial bicyclic peptide from chemical space against multidrug resistant Gram-negative bacteria.
Chem Commun (Camb)
; 54(40): 5130-5133, 2018 May 15.
Article
en En
| MEDLINE
| ID: mdl-29717727
ABSTRACT
We used the concept of chemical space to explore a virtual library of bicyclic peptides formed by double thioether cyclization of a precursor linear peptide, and identified an antimicrobial bicyclic peptide (AMBP) with remarkable activity against several MDR strains of Acinetobacter baumannii and Pseudomonas aeruginosa.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Péptidos Cíclicos
/
Péptidos Catiónicos Antimicrobianos
/
Farmacorresistencia Bacteriana Múltiple
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Antibacterianos
Límite:
Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article