Discovery of potent polyphosphate kinase 1 (PPK1) inhibitors using structure-based exploration of PPK1Pharmacophoric space coupled with docking analyses.

Bashatwah, Rasha M; Khanfar, Mohammad A; Bardaweel, Sanaa K

Bashatwah, Rasha M; Khanfar, Mohammad A; Bardaweel, Sanaa K.

Bashatwah RM; Department of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Amman, Jordan.
Khanfar MA; Heinrich-Heine-Universitaet Duesseldorf, InstitutfuerPharmazeutische and MedizinischeChemie, Duesseldorf, Germany.
Bardaweel SK; Department of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Amman, Jordan.

J Mol Recognit ; 31(10): e2726, 2018 10.

Article en En | MEDLINE | ID: mdl-29740895

Asunto(s)

Inhibidores Enzimáticos/química; Inhibidores Enzimáticos/farmacología; Fosfotransferasas (Aceptor del Grupo Fosfato)/antagonistas & inhibidores; Biopelículas; Escherichia coli/efectos de los fármacos; Escherichia coli/enzimología; Virulencia

Palabras clave

PPK1 inhibitors; PolyP; bacterial resistance; biofilm; metabolic phenotype; structure-based aided design

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fosfotransferasas (Aceptor del Grupo Fosfato) / Inhibidores Enzimáticos Idioma: En Año: 2018 Tipo del documento: Article

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