Longitudinal study on the occurrence in pigs of colistin-resistant Escherichia coli carrying mcr-1 following the cessation of use of colistin.
J Appl Microbiol
; 125(2): 596-608, 2018 Aug.
Article
en En
| MEDLINE
| ID: mdl-29741287
ABSTRACT
AIMS:
In 2015, colistin-resistant Escherichia coli and Salmonella with the mcr-1 gene were isolated from a pig farm in Great Britain. Pigs were subsequently monitored over a ~20-month period for the occurrence of mcr-1-mediated colistin resistance and the risk of mcr-1 E. coli entering the food chain was assessed. METHODS ANDRESULTS:
Pig faeces and slurry were cultured for colistin-resistant E. coli and Salmonella, tested for the mcr-1 gene by PCR and selected isolates were further analysed. Seventy-eight per cent of faecal samples (n = 275) from pigs yielded mcr-1 E. coli after selective culture, but in positive samples only 0·2-1·3% of the total E. coli carried mcr-1. Twenty months after the initial sampling, faecal samples (n = 59) were negative for E. coli carrying mcr-1.CONCLUSIONS:
The risk to public health from porcine E. coli carrying mcr-1 was assessed as very low. Twenty months after cessation of colistin use, E. coli carrying mcr-1 was not detected in pig faeces on a farm where it was previously present. SIGNIFICANCE AND IMPACT OF THE STUDY The results suggest that cessation of colistin use may help over time to reduce or possibly eliminate mcr-1 E. coli on pig farms where it occurs.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Colistina
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Proteínas de Escherichia coli
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Farmacorresistencia Bacteriana
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Escherichia coli
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Infecciones por Escherichia coli
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Antibacterianos
Tipo de estudio:
Observational_studies
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Risk_factors_studies
Límite:
Animals
Idioma:
En
Año:
2018
Tipo del documento:
Article