Alteration of nociceptive integration in the spinal cord of a rat model of Parkinson's disease.
Mov Disord
; 33(6): 1010-1015, 2018 Jul.
Article
en En
| MEDLINE
| ID: mdl-29774960
ABSTRACT
BACKGROUND:
Pain is a major non motor symptom that contributes to impaired quality of life in PD. However, its mechanism is unknown. OBJECTIVES ANDMETHODS:
We sought to identify the pain phenotypes and parallel changes in spinal integration of peripheral stimuli in a rat model of PD induced by lesions of SN dopamine neurons, using behavioral plantar and von Frey tests as well as electrophysiology of the dorsal horn.RESULTS:
We show that dopamine depletion by 6-OHDA induced hypersensitivity to mechanical and thermal stimuli. These abnormal behaviors were paralleled by increased neuronal responses and hyperexcitability of wide dynamic range neurons of lamina V of the dorsal horn of the spinal cord in response to electrical stimulation of the sciatic nerve in the 6-OHDA model as compared to sham rats.CONCLUSIONS:
These results provide evidence for alteration of nociceptive integration in the spinal dorsal horn neurons in 6-OHDA rats that can reflect changes in pain behavior. © 2018 International Parkinson and Movement Disorder Society.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson Secundaria
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Médula Espinal
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Hiperalgesia
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Hipercinesia
Límite:
Animals
Idioma:
En
Año:
2018
Tipo del documento:
Article