Two years of maintenance hemodialysis has a pronounced effect on arterial stiffness progression.
Aging Clin Exp Res
; 31(2): 193-199, 2019 Feb.
Article
en En
| MEDLINE
| ID: mdl-29779091
ABSTRACT
BACKGROUND:
The change of aortic stiffness, but not the particular baseline value, plays a crucial role in estimating the patient risk with end-stage renal disease. Therefore, we aimed to analyze the evolution of central and peripheral arterial stiffness in hemodialysis population without previous cardiovascular events during a 2-year follow-up.METHODS:
60 hemodialysis patients (mean age 57.61 ± 13.01 years) were prospectively interviewed, and they underwent blood tests, chest X-ray for aortic calcification evaluation and pulse wave velocity (PWV) measurements at the baseline, after 6 months and after 2 years of observation period.RESULTS:
We found significant progression of aortic PWV (12.73 vs. 14.24 m/s, p = 0.032) and regression of brachial PWV (11.53 vs. 8.85 m/s, p < 0.001). CRP increase influenced evolution of aortic PWV (ß = 0.331, p = 0.031, R2 = 0.599). Higher ß2-microglobulin values was related to the progression of aortic PWV (ß = 0.219, p = 0.022, R2 = 0.568). Mean arterial blood pressure had influence only on the short-term arterial stiffness evolution.CONCLUSIONS:
Patients on maintenance hemodialysis experience pronounced changes of arterial stiffness during the 2-year follow-up period. The progression of aortic stiffness is related to inflammatory response and particularly is influenced by ß2-microglobulin concentration and aortic calcification.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Diálisis Renal
/
Rigidez Vascular
Tipo de estudio:
Etiology_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Año:
2019
Tipo del documento:
Article