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Tailoring acyclovir prodrugs with enhanced antiviral activity: rational design, synthesis, human plasma stability and in vitro evaluation.
Chayrov, Radoslav L; Stylos, Evgenios K; Chatziathanasiadou, Maria V; Chuchkov, Kiril N; Tencheva, Aleksandra I; Kostagianni, Androniki D; Milkova, Tsenka S; Angelova, Assia L; Galabov, Angel S; Shishkov, Stoyan A; Todorov, Daniel G; Tzakos, Andreas G; Stankova, Ivanka G.
  • Chayrov RL; Department of Chemistry, South-West University "Neofit Rilski", Blagoevgrad, Bulgaria.
  • Stylos EK; Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, 45110, Ioannina, Greece.
  • Chatziathanasiadou MV; Biotechnology Laboratory, Department of Biological Applications and Technology, University of Ioannina, 45110, Ioannina, Greece.
  • Chuchkov KN; Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, 45110, Ioannina, Greece.
  • Tencheva AI; Department of Chemistry, South-West University "Neofit Rilski", Blagoevgrad, Bulgaria.
  • Kostagianni AD; Department of Chemistry, South-West University "Neofit Rilski", Blagoevgrad, Bulgaria.
  • Milkova TS; Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, 45110, Ioannina, Greece.
  • Angelova AL; Department of Chemistry, South-West University "Neofit Rilski", Blagoevgrad, Bulgaria.
  • Galabov AS; Department of Tumor Virology, German Cancer Research Center, Heidelberg, Germany.
  • Shishkov SA; Department of Virology, Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
  • Todorov DG; Department of Virology, Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
  • Tzakos AG; Laboratory of Virology, Sofia University "St. Kliment Ohridski", Sofia, Bulgaria.
  • Stankova IG; Laboratory of Virology, Sofia University "St. Kliment Ohridski", Sofia, Bulgaria.
Amino Acids ; 50(8): 1131-1143, 2018 Aug.
Article en En | MEDLINE | ID: mdl-29779181
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Aciclovir / Ácidos y Sales Biliares / Profármacos / Herpesvirus Humano 2 / Herpesvirus Humano 1 / Herpesvirus Humano 4 Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Aciclovir / Ácidos y Sales Biliares / Profármacos / Herpesvirus Humano 2 / Herpesvirus Humano 1 / Herpesvirus Humano 4 Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article